Neuronal GPR75 deficiency protects against diet-induced obesity in a humanized mouse model.

Xue-Nan Sun, Jan-Bernd Funcke, Chanmin Joung, Chao Li, Ayanna Cobb, Toshiharu Onodera, Joselin Velasco, May-Yun Wang, Patrick Joseph Antonellis, Christopher Mazzone, Jared Senfeld, Minrong Ai

Science advances

2026

Journal Article

Animals, Obesity, Receptors, G-Protein-Coupled, Mice, Disease Models, Animal, Energy Metabolism, Humans, Diet, High-Fat, Neurons, Adipose Tissue, Brown, Brain, Adipocytes, Adipose Tissue, White, Mice, Knockout