Mechano responsiveness of neuroimmune cross-talk in bone and joints: A narrative review with implications for force-based manipulations.

Karl J Lewis, Jennifer Bent, Per Gunnar Brolinson, Damian Keter, Ellen Lumpkin, Jan Mundo, Vitaly Napadow, William R Reed, Brent S Russell, Simon Y Tang, Mary F Barbe

Musculoskeletal science & practice

2026

Journal Article, Review, Research Support, N.I.H., Extramural

Neuroimmunomodulation, Musculoskeletal Manipulations, Humans, Bone and Bones, Joints, Acupuncture, Cytokines, Hydrocortisone, Parasympathetic Nervous System, Sympathetic Nervous System, Intercellular Signaling Peptides and Proteins, Signal Transduction, Osteogenesis, Animals, Bone Marrow, Bone Remodeling